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KMID : 1156220100360020155
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Journal of Environmental Health Sciences
2010 Volume.36 No. 2 p.155 ~ p.162
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Biomonitoring of Aflatoxin B1 Exposed by Herbal Medicine Intake
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Lee Jin-Hee
Ryu Heui-Young
Kim Hyun-Kyung
Kim Do-Jung
Lee Young-Joo
Jung Su-Hee
Jang Dong-Deuk
Kim Hyung-Soo
Yoon Hae-Seong
Hong Yeon-Pyo
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Abstract
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Aflatoxin B , a known human carcinogen, is the member of aflatoxin subfamily that is most frequently found in con 1 taminated foods. Epidemiological studies have suggested that aflatoxins may be associated with human liver cancer and acute hepatitis. Recently it was reported that the traditional medical herbs sold in domestic markets are contaminated with aflatoxins. Long-term administration of these contaminated medicines could result in adverse health effects. Therefore, it is important to evaluate the levels of exposure to aflatoxin in people who ingest traditional herbal medicines. Blood samples were collected, before and after the herbal medicine intake, from 151 subjects who visited the hospital. The metabolite of aflatoxin B in blood, aflatoxin B-albumin (aflatoxin B-lysine), is reportedly an appropriate internal 11 1 exposure indicator, and its levels in the collected bloods were therefore analyzed using a liquid chromatography-mass spectrometry. The analytical method of aflatoxin B-lysine in blood was firstly optimized in Korea and the levels were 1 detected below quantification limits (2 pg/mg albumin) in this study population. Consequently, the exposure levels of aflatoxin B by ingestion of herbal medicines were low but it is important to monitor routinely due to the possibility 1 of risk on the aflatoxin exposure.
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KEYWORD
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aflatoxin B, biomonitoring, blood, herbal medicine
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